Research
Drug resistance of tumor cells is the cause of treatment failure for most human cancers.  Acquired resistance was observed in the very first trial of a chemotherapeutic in 1942.  Since that time, vast improvements in chemotherapy- including novel drugs, combination therapies, reduced toxicity, and highly targeted treatments- have extended the lives of many cancer patients.  Yet drug resistance remains a major scientific and clinical challenge in the treatment of human cancer. 
     
​Tumor cell populations are characterized by enormous heterogeneity and plasticity. This variation contributes to disease progression and response to therapy, although the mechanisms are not yet well understood.  To address these challenges, we are developing novel technologies and experimental systems rooted in the tools of systems and synthetic biology and bioengineering. 
Lab News 
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10/2018  Welcome to new BME graduate student Daylin Morgan!

9/2018  Aziz's paper on the COLBERT barcoding platform is published in ACS Syn Bio.

7/2018  Congratulations to Eric on being selected for the F.M. Jones and H.L. Bruce Endowed Graduate Fellowship!

6/2018 Our barcoding technology, COLBERT, is discussed in Nature Methods and you can learn more here.

5/2018 The lab is happy to welcome graduate student Eric Brenner!  Read more about his work on the Team page!

5/2018  Aziz presented the multi-functional capabilities of his cell barcoding platform at the Fifth International Workshop in Mammalian Synthetic Biology in Boston.
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 ​4/2018   Kaitlyn has been awarded a competitive NSF Graduate Research Fellowship!  Congratulations to Kaitlyn on this recognition of her research and leadership contributions!